Recommended GAZYVA Infusion Rates at Selected Concentrations 1


Dilute GAZYVA with 0.9% sodium chloride to achieve a final concentration ranging from 0.4 mg/mL to 4 mg/mL.

  • Do not use other diluents such as dextrose (5%)

Cycle 1, Day 1 (100 mg dose):

  • Administer at 25 mg/hr over 4 hours. Do not increase the infusion rate
  • The Day 1 dose for GAZYVA is 100 mg in 100 mL

Cycle 1, Day 2 (900 mg dose):

  • If no infusion reaction occurred during the previous infusion, administer at 50 mg/hr. The rate of the infusion can be escalated in increments of 50 mg/hr every 30 minutes to a maximum rate of 400 mg/hr
  • If an infusion reaction occurred during the previous infusion, administer at 25 mg/hr. The rate of infusion can be escalated in increments of up to 50 mg/hr every 30 minutes to a maximum rate of 400 mg/hr

Cycle 1, Days 8 &15; Cycles 2-6 (1,000 mg dose):

  • If no infusion reaction occurred during the previous infusion and the final infusion rate was 100 mg/hr or faster, infusions can be started at a rate of 100 mg/hr and increased by 100 mg/hr increments every 30 minutes to a maximum of 400 mg/hr
  • If an infusion reaction occurred during the previous infusion, administer at 50 mg/hr. The rate of infusion can be escalated in increments of 50 mg/hr every 30 minutes to a maximum rate of 400 mg/hr