GAZYVA preparation and storage for R/R follicular lymphoma 1

Prepare the GAZYVA solution for infusion using aseptic technique as follows:

STEP 1
  • Inspect visually for any particulate matter and discoloration prior to administration
STEP 2
  • Dilute into 0.9% sodium chloride PVC or non-PVC polyolefin infusion bag
  • Do not use other diluents such as dextrose (5%)
STEP 3
  • Withdraw 40 mL of GAZYVA solution from the vial
  • Dilute 40 mL (1000 mg) into a 250 mL 0.9% sodium chloride infusion bag
STEP 4
  • Mix diluted solution by gentle inversion
  • Do not shake or freeze

Additional preparation information

  • For microbiological stability, the diluted GAZYVA infusion solution should be used immediately
  • Dilute under appropriate aseptic conditions
  • If not used immediately, the solution may be stored in a refrigerator at 2°C to 8°C (36°F to 46°F) for up to 24 hours prior to use
  • The product can be administered at a final concentration of 0.4 mg/mL to 4 mg/mL

Additional storage information

  • GAZYVA 1000 mg/40 mL (25 mg/mL) single-dose vials containing preservative-free solution (NDC 50242-070-01) are stable at 2°C to 8°C (36°F to 46°F)
  • Do not use beyond expiration date stamped on carton
  • Protect GAZYVA vials from light
  • DO NOT FREEZE
  • DO NOT SHAKE